William H. Macy

Lefty Maginnis (voice)

Rob Reiner

Screwie (voice)

Brian Dennehy

Babe Ruth (voice)

Jake T. Austin

Yankee Irving (voice)

Cherise Boothe

Rosetta Brewster (voice)

Whoopi Goldberg

Darlin' (voice)

Jason Harris

Announcer (voice)

Ed Helms

Hobo Louie (voice)

Ray Iannicelli

Conductors / Umpire (voice)

Gideon Jacobs

Bully Kid Tubby (voice)